Targeting senescent cells with NKG2D-CAR T cells


Yushuang Deng, Avadh Kumar, Kan Xie, Kristina Schaaf, Enzo Scifo, Sarah Morsy, Tao Li, Armin Ehninger, Daniele Bano and Dan Ehninger

This study demonstrates the efficacy of NKG2D chimeric antigen receptor (CAR) engineered T cells in targeting and eliminating stress induced senescent embryonic fibroblasts (MEFs) and astrocytes (AST) paving the way for future investigations into the therapeutic applicability of NKG2D-targeting CAR-T cells in naturally aged organisms and models of aging-associated brain diseases in vivo.
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