Author name: PE-supervisor-1

Targeting senescent cells with NKG2D-CAR T cells

This study demonstrates the efficacy of NKG2D chimeric antigen receptor (CAR) engineered T cells in targeting and eliminating stress induced senescent embryonic fibroblasts (MEFs) and astrocytes (AST) paving the way for future investigations into the therapeutic applicability of NKG2D-targeting CAR-T cells in naturally aged organisms and models of aging-associated brain diseases in vivo.

Rethinking the role of microglia in obesity

The article discusses recent data on how microglial energy metabolism changes after consuming an obesogenic diet and its impact on hypothalamic neuron activity. It also emphasizes studies uncovering the mechanisms behind obesity-related sexual dimorphism.

Glucose-derived glutamate drives neuronal terminal differentiation in vitro

Little is known about the metabolic pathways governing neuronal maturation and the acquisition of their final characteristic in terms of morphology and electrical activity.

Here, the authors investigate the contribution of the main metabolic pathways, namely glucose, glutamine, and fatty acid oxidation, during this process.

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