Glucose-derived glutamate drives neuronal terminal differentiation in vitro

Authors:

Laura D’Andrea, Matteo Audano, Silvia Pedretti, Silvia Pelucchi, Ramona Stringhi, Gabriele Imperato, Giulia De Cesare, Clara Cambria, Marine H Laporte, Nicola Zamboni, Flavia Antonucci, Monica Di Luca, Nico Mitro & Elena Marcello

Little is known about the metabolic pathways governing neuronal maturation and the acquisition of their final characteristic in terms of morphology and electrical activity. Here, the authors investigate the contribution of the main metabolic pathways, namely glucose, glutamine, and fatty acid oxidation, during this process.

EMBO Rep. 2024;25(3):991-1021. doi: 10.1038/s44319-023-00048-8.

Little is known about the metabolic pathways governing neuronal maturation and the acquisition of their final characteristic in terms of morphology and electrical activity.

Here, the authors investigate the contribution of the main metabolic pathways, namely glucose, glutamine, and fatty acid oxidation, during this process.

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